منابع مشابه
Orally active prostacyclin analogue in primary pulmonary hypertension.
Primary pulmonary hypertension is a disease of unknown aetiology that is progressive and uniformly fatal. However, substantial improvement in the duration and quality of life has been reported in patients who have received long-term intravenous prostacyclin (PGI2) infusion. But this treatment is more uncomfortable for patients and potentially more hazardous than oral therapy. On the other hand,...
متن کاملProstacyclin Analogue Beraprost Inhibits Cardiac Fibroblast Proliferation Depending on Prostacyclin Receptor Activation through a TGF β-Smad Signal Pathway
Previous studies showed that prostacyclin inhibited fibrosis. However, both receptors of prostacyclin, prostacyclin receptor (IP) and peroxisome proliferator-activated receptor (PPAR), are abundant in cardiac fibroblasts. Here we investigated which receptor was vital in the anti-fibrosis effect of prostacyclin. In addition, the possible mechanism involved in protective effects of prostacyclin a...
متن کاملA prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice
BACKGROUND Metabolites of arachidonic acid such as prostacyclin (PGI2) have been shown to participate in the pathogenesis of pulmonary fibrosis by inhibiting the expression of pro-inflammatory and pro-fibrotic mediators. In this investigation, we examined whether iloprost, a stable PGI2 analogue, could prevent bleomycin-induced pulmonary inflammation and fibrosis in a mouse model. METHODS Mic...
متن کاملLong term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue.
OBJECTIVE To evaluate the effects of one year's treatment with beraprost, an orally active prostacyclin analogue, in patients with severe pulmonary hypertension. PATIENTS 13 patients with severe pulmonary hypertension. This was primary in nine, thromboembolic in three, and caused by Eisenmenger syndrome in one. METHODS All patients underwent right heart catheterisation. Mean (SD) right atri...
متن کاملProtective effect of beraprost sodium, a stable prostacyclin analogue, on cardiac allograft vasculopathy in rats.
Intimal thickening and luminal narrowing of the coronary arteries are insidious complications of cardiac allograft. However, the pathogenesis of cardiac allograft vasculopathy (CAV) remains to be clarified. In this study, the protective effect of a prostacyclin analogue (beraprost sodium; BPS) on CAV was evaluated after heterotopic cardiac transplantation in rat. All recipients were treated wit...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2010
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.99.1563